AR and posterior cortical atrophy: Aberrant activation of androgen receptor (AR) is closely related to the occurrence and progress of PCa.[1] AR is a member of the nuclear receptor superfamily and consists of four distinct functional domains: the N‐terminal domain (NTD), the DNA‐binding domain (DBD), the hinge region, and the ligand binding domain (LBD).[2] The receptor is normally located in the cytoplasm and remains inactive by binding with heat shock proteins (HSPs) and cytoskeletal proteins.