IL-1β-producing CD68+CD163+ macrophages also expressed AFF3 (AF4/FMR2 family member 3, or LAF4), which encodes a tissue‐restricted nuclear transcriptional activator that is possibly involved in lymphoid cell development [53] and has been identified as an important player in the onset and development of cancers including glioblastoma [54]. This evidence concerns the gene AFF3 and cancer.