LAMB2 and cancer: In line with our observations, LAMININ signaling has been implicated in tumor progression and EMT by promoting the breakdown of collagen IV (α1) to facilitate migration (Liu et al, 2018; Zeisberg and Neilson, 2009) and a few reports have proposed that LAMININ signaling regulates the resistance of cancer cells to therapeutic agents (Weaver et al, 2002; Yang et al, 2010).