To determine if p53 also regulates sensitivity to MET inhibition in human MPNSTs, we screened a panel of 6 NF1-related and 1 sporadic (STS26T) MPNST cell lines for functional p53 based on sensitivity to the p53 stabilizing drugs, MI-773 and nutlin-3a. This evidence concerns the gene NF1 and malignant peripheral nerve sheath tumor.