Recent evidence has shown that HR deficient breast and ovarian cancers have an increased dependency on oxidative phosphorylation (OXPHOS) rather than glycolysis for energy metabolism and that HRD tumor cells have elevated complex I respiratory chain subunits, such as NADH:Ubiquinone Oxidoreductase Core Subunit V2 (NDUFV2)40–42. Here, NDUFV2 is linked to ovarian carcinoma.