BRCA1 and neoplasm: The elevated abundance of BMI1 in HRP HGSOC tumor cells and the recently described43 role of BMI1 in regulating homologous recombination repair supports the increased sensitivity of HRP (UWB1.289 + BRCA1) cells to PTC-028 and suggests these cells are more dependent on BMI1 than HRD (UWB1.289) HGSOC cells.