We validated a number of these proteins in CPTAC HGSOC data, namely TIMP3, a protease localized to the extracellular matrix that has previously been correlated with poor OS in HGSOC33, and MXRA8, a transmembrane protein that has been identified as a marker of cancer-associated fibroblasts in pancreatic cancer34 that also correlates with poor outcome in glioma35. The gene discussed is TIMP3; the disease is cancer.