Previous studies have shown that PRODH is linked to Complex II of the mitochondrial electron transport chain in mitochondrial inner membranes (Phang, 2019) and its expression resulted in a dose-dependent down-regulation of Complexes I–IV of the ETC in human colorectal adenocarcinoma epithelial cells (Hancock et al, 2015). This evidence concerns the gene PRODH and colorectal adenocarcinoma.