Five reactions associated with the folate metabolism (MTHFDm, MTHFDm2, MTHFCm, MTHFD, MTHFD2) were associated with genes differently expressed in AD, three reactions (VMH IDs: PGCD, PSERT, and PSP_L), which are involved in the catabolism of 3-phosphoglycerate through an alternative pathway from glycolysis with the production of L-serine, a possible precursor of formate, were associated with genes overexpressed in AD; this result could corroborate the reported reduction in glycolysis intermediate concentrations in AD participants50. The gene discussed is MTHFD2; the disease is Alzheimer disease.