Additionally, their expression was higher in GC tissue respect to normal gastric tissue in both cohorts (Fig. 6I), whereas high expression of MATN3, TIMP1 and DKK1 was significantly associated with reduced OS and DFS in GC patients from the TCGA, ACRG and the additional cohorts used in this study (Fig. 6J), their expression being also significantly elevated in the samples of those patients presenting metastasis (Fig. 6K). Here, DKK1 is linked to gastric cancer.