ITIH3 and gastric cancer: From this, and taking advantage of computational biology tools, additional patient datasets, clinical information and functional studies, we identified a novel gene signature related to recurrence and metastasis in GC, highlighting the special relevance of ANKRD6 and ITIH3, which represent novel potential biomarkers for GC progression, EMT and metastasis, as well as suitable targets for the improvement of the management of the disease.