APP and Alzheimer disease: We established methods and tools such as a cultivating system for organotypic brain slices producing N-terminally truncated Aβ from endogenous APP as well as a neo-epitope-specific antibody to detect sAPPβ + Asp, which will likely be helpful for future AD-related studies to examine APP cleavage by different β-secretases and the contribution of different Aβ peptides to AD pathophysiology.