Obesity is a state of low‐grade chronic inflammation, during which, signaling via cytokines of the TNF family mediate cell death and inflammation within the adipose tissue, eventually resulting in lipid spill‐over, glucotoxicity and insulin resistance, ultimately lead to ectopic lipid deposition, glucose intolerance and other metabolic complications with life‐threatening consequences [46]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.