SPRY4 and osteoarthritis: Endogenous glucocorticoids play a role in the disease progression of osteoarthritis.63 Our Hi-C data reveal a single loop connecting the active promoters of SPRY4 (sprouty RTK signalling antagonist 4) and/or the promoter of the SPRY4-antisense RNA 1 (figure 4A, online supplemental table 9 and online supplemental figure 10), with active enhancers with the credible set variants identified.