For osteoarthritis, a recent study identified a potential novel anti-inflammatory gene by integrating Hi-C data from cultured chondrocyte cells with CUT&RUN and RNA-sequencing data from fibronectin-treated cells.76 Examining chromosomal conformation in primary tissue offers advantages, as it accurately captures the in vivo spatial organisation of chromosomes, closely resembling the actual regulatory conditions in the disease-relevant cell types. This evidence concerns the gene FN1 and osteoarthritis.