However, a recent publication reported that oral administration of RG7834 (a small-molecule dihydroquinolizinone inhibitor of the terminal nucleotidyltransferases 4A and B (TENT4A/B)) in HAV-infected Ifnar1-/- mice completely blocked viral infection and provided strong attenuation of hepatitis-induced elevation of serum ALT levels [21]. Here, IFNAR1 is linked to viral infectious disease.