Polymorphisms in genes associated with the regulation of calcium levels (CASR, CYP24A1, CARS, DGKD, DGKH/KIAA0564 and GATA3) [48] and metalloproteinases (MMP-3 and MMP-9) [49] were also associated with an increased risk of coronary artery disease and AMI. This evidence concerns the gene CARS1 and coronary artery disorder.