Thyroid differentiation-related genes (TG, TSHR, and PAX8) were upregulated in PTC-Epis and downregulated in ATC-Epis, which revealed a potential dedifferentiation process in thyroid cancer progression (Figure 2B, Supplemental Figure 2C, and Supplemental Table 3) (13). Here, TSHR is linked to thyroid gland carcinoma.