The stress response included outcomes such as epinephrine, norepinephrine, dopamine, cortisol, and heart rate (HR) whereas pro-inflammatory/anti-inflammatory response included tumour necrosis factor (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), erythrocyte sedimentation rate (ESR), Ankylosing Spondylitis Disease Activity Score C-reactive protein (ASDAS-CRP), calprotectin, high-sensitivity C-reactive protein (hs-CRP), and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). This evidence concerns the gene TNF and ankylosing spondylitis.