As a proof-of-principal, we tested the efficiency of SPQ by quantifying viral read counts from three published 10× scRNAseq cell virus infection experiments (Table 2), including two SARS-CoV-2 infection experiments in human lung and bronchial epithelial cells and an experiment in a CD4 T cell model of HIV viral infection and latency. The gene discussed is CD4; the disease is viral infectious disease.