The first Cancer Predisposition Gene (CPG) testing occurred in Manchester in 1990, with the discovery of the TP53 gene as a high-risk gene for Li Fraumeni syndrome [1], followed by BRCA1, BRCA2 and Lynch (MLH1, MSH2, MSH6 and PMS2) genes in 1991–1995. The gene discussed is BRCA2; the disease is cancer.