It is notable that the detection of 2225 index cases for BRCA1/2 and Lynch syndrome combined at MCGM has led to the subsequent identification of over 2989 positive family members, who can then benefit from cancer prevention and early detection strategies resulting in both individual, and societal health economic benefit, Equally important is the reassurance for close to 3000 family members testing negative as well as all their offspring who, for the most part can be reassured regarding risk. The gene discussed is BRCA1; the disease is Lynch syndrome.