TGFB1 and colorectal carcinoma: In view of this phenomenon, CRC consensus molecular subtypes (CMS) (Guinney et al. 2015), a recently established classification based on the transcriptome data may provide an explanation, in which the CMS4 (mesenchymal), characterized by prominent transforming growth factor β (TGF-β) activation, stromal invasion, and angiogenesis, are associated with poor prognosis, and suggest the importance of cancer-associated fibroblasts (CAF), the major component of the stroma, to the prognosis of CRC patients.