The proteomic data obtained from CAF derived from AOM/DSS-induced CRC mice and normal mice-derived NF indicate that in addition to commonly known CAF-related proteins (such as COL3A1, COL1A2, and FBN1), IGFBP7 and FSTL1 were significantly upregulated in the CAF conditioned medium (Fig. 8E). The gene discussed is NFASC; the disease is infectious otitis media.