In our study, we observed a higher prevalence of HLA-Bw4 motifs together with KIR3DL1 and an increased prevalence of the two NK cell educating KIR-HLA ligand pairs KIR2DL1/C2 and KIR3DL1/Bw4 among MM patients. This evidence concerns the gene KIR3DL1 and Miyoshi myopathy.