VEGF, a proinflammatory mediator plays a crucial role in angiogenesis.(10) VEGF contributes to the severity of inflammation in gingivitis and periodontitis by inducing the emergence of new blood vessels, which facilitate the transport of proinflammatory cells, nutrients, and oxygen to inflamed tissues.(16) Previous studies on peri-implantitis have demonstrated controversial levels of VEGF in peri-implant tissues;(12) however, in this study, no significant difference was observed in the levels of this growth factor between groups. This evidence concerns the gene VEGFA and Peri-Implantitis.