HIF1A and Peri-Implantitis: Our findings corroborate a study in mice infected with Histoplasma capsulatum, which demonstrated that the absence of HIF-1α in the infected mice caused an increase in the IL-10 cytokine and consequent increase in the fungal load and death of most animals.(26) Together, these findings suggest that the increase in the anti-inflammatory cytokine IL-10 could reduce the inflammatory condition in peri-implantitis with an improvement of tissue hypoxia, evident from the reduced HIF-1α levels.