INS and Hyperglycemia: Insulin receptor signaling, (via the insulin/IGF‐1R signaling pathway), controls osteoblast development and osteocalcin expression, where knockout mice displayed decreased bone formation due to a deficient number of osteoblasts.[202] Notably, and with age, these mice develop marked adiposity and hyperglycemia, indicating a bone‐endocrine (osteocalcin) loop that regulates bone and fat tissue formation via glucose metabolism.