TNFSF11 and osteoporosis: Osteoclastogenesis is promoted by RANKL, an essential signaling molecule that binds to its receptor (RANK) on osteoclast precursors, thereby initiating osteoclast differentiation and ultimately, bone resorption.[76] To investigate the effects of P7C3 on RANKL expression as OVX‐induced osteoporosis progresses, we performed RANKL IHC staining on sections prepared through the femoral condyle.