The janus kinases (JAKs) are a family of protein tyrosine kinases that act on signal transducer and activator of transcription (STAT), a signaling pathway that serves as an important downstream mediator for a variety of cytokines, hormones, and growth factors, as well as for osteoblast, and osteoclast proliferation and differentiation.[126, 127] Further, emerging evidence suggests STAT3 and its network, participates in the development of osteoporosis.[128] Our GO data reveal the significant P7C3‐induced increase in regulation of receptor signaling pathway via JAK/STAT and STAT. The gene discussed is STAT3; the disease is osteoporosis.