Our data reveals the highest, and >5‐fold reduction in serum levels of TrkA, a neurotrophin expressed by sensory neurons within bone, a central mediator of bone pain,[97] a suppressor of osteoprogenitor number,[98] and a protein that is essential for bone repair.[99] However, its role in osteoporosis remains elusive. The gene discussed is NTRK1; the disease is osteoporosis.