TNFRSF11B and obesity due to melanocortin 4 receptor deficiency: Finally, both Estradiol and P7C3 downregulated levels of the protein Fas, where increased Fas expression has been shown to contribute to adipose tissue dysfunction, mediate inflammatory signals in obesity, and reduce adipogenesis.[208, 209, 210] Reduced levels of Fas are also associated with an increased resistance to OVX‐induced bone loss via increase OPG expression.[211]