The RNA‐binding protein LUC7L2 is a splicing factor that is involved in disease onset and progression through alternative RNA splicing, including intron retention.[12, 25] In fact, considerable splicing changes, such as intron retention, are frequently seen in tumor cells and linked to the advancement and recurrence of cancer.[26] It has been demonstrated that up to 80% of human protein‐coding genes are affected by intron retention.[27] Moreover, intron retention is also exclusive to certain tissues and cell types. This evidence concerns the gene SLU7 and neoplasm.