Histone lactylation increases bevacizumab resistance in colorectal cancer via promoting the expression of the autophagy enhancer protein RUBCNL.[8] In addition, lactylation in GBM is associated with self‐renewal of stem cells, CAR‐T therapy and vasculogenic mimicry.[9] However, whether lactylation plays a role in GBM TMZ resistance has not yet been reported, and further in‐depth investigation is urgently needed. The gene discussed is RUBCNL; the disease is glioblastoma.