The reduced intensities of rRNA degradation in Delta and Omicron infection (Fig. 6C) could be due to delayed progression of infection, as indicated by lower nucleocapsid (N) levels (Fig. 6B) and titer (Fig. S2C) in A549ACE2 cells, rather than a muted response by the RNase L pathway. The gene discussed is RNASEL; the disease is infection.