Based on our previous study (Costa et al., 2019), where AQP4 was overexpressed both during central nervous system development and in human glioma cells and triiodothyronine (T3) played a negative role in this expression pattern, we chose tree-specific pathways in the downregulated list of the functional enrichment analysis: hsa00350 (Tyrosine metabolism [9 genes]); hsa04918 (Thyroid hormone synthesis [15 genes]); and hsa04919 (Thyroid hormone signaling pathway [7 genes]) (Supplementary Table 3). The gene discussed is AQP4; the disease is glioma.