AQP4 and hypothyroidism: This could result in the overexpression of AQP1 and AQP4 in the more aggressive glioma subtypes [astrocytoma (LGG) and classical, (GBM)], as we present in the differential expression results, (2) hypothyroidism would already be a clinical risk condition for the development of glioma; patients diagnosed early with the tumor would present a sub-clinical pattern of thyroid gland dysfunction.