AQP4 and stroke disorder: We previously identified a negative modulator of AQP4 protein and demonstrated that triiodothyronine (T3) treatment of GBM-95-line cells resulted in a slight reduction in cell migration (Costa et al., 2019); other studies have also evaluated the modulatory action of this hormone on the expression of AQP4 in stroke animal models (Sadana et al., 2015).