In pediatric patients, an important probability of developing thyroid dysfunction was found post-treatment with surgery, chemotherapy, and radiotherapy (Jin et al., 2018; Cosnarovici et al., 2020); moreover, abnormalities in thyroid function were found in patients with AQP4 antibody–seropositive optic neuritis (Zhao et al., 2017). The gene discussed is AQP4; the disease is optic neuritis.