Although still controversial, accumulated evidence suggests that thyroid function plays an important role in several pathological and non-pathological processes of the central nervous system, including gliomagenesis, cell migration and cerebral edema resolution (Schiera et al., 2021) having AQP4 as one of its action targets, as shown in two experimental circumstances, mentioned above, evidenced by our research group (Costa et al., 2019). Here, AQP4 is linked to thyroiditis.