A mutation in the cell adhesion protein neuroligin-3 (NLGN3) linked to ASD induces an enhancement in excitatory synaptic transmission [150], while loss of synapses in SCZ disrupts pyramidal neuron function in the cortex to elicit cognitive symptoms and disinhibits mesostriatal projections to promote dopamine overactivity and psychosis [106]. The gene discussed is NLGN3; the disease is psychotic disorder.