APOE and Alzheimer disease: In addition to this, ApoE4 is associated with multiple AD pathologies including inadequate Amyloid-β clearance (Fernandez et al., 2019; Kloske and Wilcock, 2020), neuroinflammation (Ophir et al., 2005; Fan et al., 2017), and reduced synaptic plasticity (Dumanis et al., 2009; Chen et al., 2010; Rodriguez et al., 2013; Safieh et al., 2019; Yamazaki et al., 2019).