This process is mediated by METTL1-induced translation of distinct key cytokines; human interleukin 8 (IL8) and mouse C-X-C motif chemokine 5 (Cxcl5) in ICC (83), and transforming growth factor-β2 (TGF-β2) in HCC tumors (84). This evidence concerns the gene CXCL5 and hepatocellular carcinoma.