Overexpression of the RNA methyltransferase enzyme tRNA methyltransferase 61B (TRMT61B), resposible for the m1A58 of human mt-tRNAs, has been identified across a diverse array of cancer types in the TCGA tumor collection, and its expression correlates with the histopathological tumor grade in patients with CRC, BC, ovarian carcinoma (OC) and lung adenocarcinoma (LUAD) (177). This evidence concerns the gene TRMT61B and lung adenocarcinoma.