The key mechanism of codon-biased translation is exemplified by RNA-modifying proteins such as methyltransferase-1 (METTL1) and WD repeat domain 4 (WDR4), Elongator acetyltransferase complex subunit 1–6 (ELP1–6), cytosolic thiouridylase subunit 1–2 (CTU1–2) or AlkB homolog 8 (ALKBH8)-tRNA methyltransferase 112 (TRMT112), whose gene amplifications, increased expression or increased deposition of their modifications can contribute to the promotion of cancer proliferation (22). This evidence concerns the gene WDR4 and cancer.