In liver tumors, specifically ICC (71) and HCC (77), METTL1 also governed the translation of cyclin A2 and epidermal growth factor receptor (EGFR) proteins, consequently regulating the phosphorylation of the receptor downstream targets AKT, mTOR (71) and mitogen-activated protein kinase (MAPK) (77). This evidence concerns the gene METTL1 and intrahepatic cholangiocarcinoma.