Research conducted by Schöller et al. (172), utilizing the TCGA database, found an up-regulation of METTL8 in various cancers, including diffuse large B cell carcinoma (DLBC), GBM, low-grade glioma (LGG), lung squamous cell carcinoma (LUSC), pancreatic adenocarcinoma (PAAD), stomach adenocarcinoma (STAD) and thyroid carcinoma (THYM) (172). This evidence concerns the gene METTL8 and cancer.