ALKBH8 and neoplasm: Both proteins interact with the allosteric regulator of methyltransferases, tRNA methyltransferase activator subunit 11-2 (TRMT112) (112,113), known for its interaction with other enzymes that also has a profound impact in tumor growth and translation alteration, such as ALKBH8 or TRMT9A, TRMT9B and methyltransferase 5 (METTL5) (114–116), emphasizing the intricate network of interactions crucial for cellular processes such as protein synthesis and proliferation.