CREB1 and neurodegenerative disease: Moreover, BDNF, CREB, phosphorylated CREB (phospho-CREB), and serotonin have all been shown to be sleep-promoting, and BDNF, phospho-CREB, ACh, and TrkB were all found to be increased after apigenin treatment in a mouse model of amyloid beta (Aβ)-driven neurodegenerative disease (58).