Functionally, LRRC25 is implicated in regulating autophagy during viral infection and has been shown to promote the degradation of RIG-1 and p65/RelA (Du et al., 2018) thereby negatively regulating the signaling pathways of NF-κB (Feng et al., 2017), and interferon (Du et al., 2018) and thus suppress the production of inflammatory cytokines. This evidence concerns the gene RELA and viral infectious disease.