LRRC25 and Alzheimer disease: To understand whether LRRC25 is also altered in a more relevant cellular model of AD, we cultured and maintained iPSC-derived neurons from NC and AD patient fibroblasts as detailed in the section “Materials and methods.” After a complex network of neuritis was formed, we first confirmed the neuronal phenotype by immunostainings with NeuN, a marker of mature neurons, and MAP2 which stains dendrites at 16 days in vitro (16DIV) (Figures 7A, B).