IFNG and Alzheimer disease: LRRC25’s role in neuroinflammation in AD is also intriguing given that LRRC25 overexpression impairs and LRRC25 knockout potentiates NF-κB activation thereby increasing the production of inflammatory cytokines (Feng et al., 2017), More recently LRRC25 has also been shown to inhibit IFN-γ secretion by microglia (Sheng et al., 2023).