Lack of Wnt5a results in alveolar insufficiency and modulation of this protein is being actively pursued as a potential treatment for bronchopulmonary dysplasia, a disease of prematurity where alveologenesis is impaired (Li et al., 2020; Sucre et al., 2020; Ai et al., 2022). Here, WNT5A is linked to bronchopulmonary dysplasia.