Our findings reveal a marked reduction in GLIPR2 expression, strongly associated with the clinical stage across a diverse spectrum of malignancies Additionally, ROC curve analysis highlights the latent potential of GLIPR2 as a promising diagnostic biomarker across various cancer subtypes, including but not limited to CESC, CHOL, COAD, CEAD, KICH, LUAD, and LUSC. The gene discussed is GLIPR2; the disease is cancer.