found that upregulation of CXCL1 with downregulation of SV2A and upregulation of SLAMF3 with downregulation of CHRNB3 can be constructed as a two-gene pair signature for BRCAness in ovarian cancer that predicts improved OS, PFS, and increased multi-omics alterations in homologous recombination genes. The gene discussed is LY9; the disease is ovarian cancer.