found that upregulation of CXCL1 with downregulation of SV2A and upregulation of SLAMF3 with downregulation of CHRNB3 can be constructed as a two-gene pair signature for BRCAness in ovarian cancer that predicts improved OS, PFS, and increased multi-omics alterations in homologous recombination genes. Here, LY9 is linked to ovarian carcinoma.