CD244 and triple-negative breast carcinoma: In another study, a gene analysis in triple-negative breast cancer (TNBC) showed that overexpression of Prune-1, IL-10, COL4A1, ILR1, and PDGFB, as well as inactivating mutations of PDE9A, CD244, Sirpb1b, SV140, Iqca1, and PIP5K1B genes, are associated with metastasis to the lungs, suggesting low expression of CD244 may be associated with worse prognosis.