TFAM is identified as a direct target of miRNA-590-3p; in bladder cancer, a downregulation of miRNA-590-3p expression correlates with a marked increase in TFAM expression (60), while in colon cancer, an elevation in miRNA-590-3p expression is associated with a significant decrement in TFAM expression (61). This evidence concerns the gene TFAM and malignant colon neoplasm.