Moreover, highly metastatic HCC cells were also found to secrete sEVs that were deprived of transmembrane serine protease TMPRSS2; those sEVs were found to suppress the packaging of pro-tumoral nidogen into exosomes and inhibit proliferation and migration of immortalized hepatic cell LO2 (12). This evidence concerns the gene TMPRSS2 and hepatocellular carcinoma.