Similar to HCC CSCs, CD44+ EpCAM+ colorectal CSCs secreted exosomes that were enriched in miR-200c, resulting in subsequent activation of PI3K/Akt/mTOR signaling in target cells, which suggested that the metastatic properties could be transferred from highly to lowly metastatic cells via sEVs (9). The gene discussed is EPCAM; the disease is hepatocellular carcinoma.