With MSC-sEV treatment, lncRNA C5orf66.AS1 was found to be upregulated, with consequential elevated expression of dual specificity phosphatase 1 (DUSP-1) and suppression of p-ERK, which resulted in the inhibition of malignant behavior of HCC CSCs (71). The gene discussed is DUSP1; the disease is hepatocellular carcinoma.