INS and type 2 diabetes mellitus: A potent PPAR-γ (peroxisome proliferator activator receptor-γ) agonist pioglitazone was another glucose-lowering drug that was studied for its effects on EAT in a small case–control study of 12 T2D patients versus 12 healthy controls by Moody et al.74 They demonstrated that pioglitazone reduces the EAT volume and that the reduction in EAT size is associated with an improvement in insulin sensitivity.74