Hypoxia within adipose tissue, in turn, can lead to adipocyte insulin resistance through inhibition of insulin receptor tyrosine phosphorylation and decreased glucose transport.37 Failure to store fat effectively increases dyslipidaemia and ectopic fat deposition in tissues such as the skeletal muscle and liver, which further impairs insulin signalling in conditions such as T2D and obesity.38 This evidence concerns the gene INS and type 2 diabetes mellitus.