UCP1 and coronary artery disorder: However, suggesting a potential causal relationship, endothelial microparticles carrying microRNAs have been shown to contribute to atherosclerosis by causing inflammation in perivascular adipose tissue, which is a form of EAT in close proximity to coronary arteries.27 Moreover, BAT-specific genes such as UCP-1, PGC-1α, bone morphogenetic protein 7 and PR/SET domain 16 were found to be lower in EAT from patients with CAD than in EAT from those without CAD.26 These findings were interpreted as a transition of brown features of EAT to white or beige features in the presence of CAD.