In current study, by using Itpr2 conditional knockout mice (Itpr2 cKO) from our previous study,[7] and generating another inducible Itpr2 conditional knockout mice line (Itpr2 iKO), we confirmed that ITPR2 is required for proper myelination and its depletion in OLs induced anxiety/depression‐like behaviors in the animals. The gene discussed is ITPR2; the disease is Anxiety.