ESR1 and breast carcinoma: Among different subtypes of breast cancer, triple-negative breast cancer (TNBC) with negative expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) is more malignant, easy to disseminate, and has no effective treatment and poor prognosis (Garrido-Castro et al., 2019; Kalimutho et al., 2015).