CARM1 and cancer: To explore whether CARM1 promotes cancer development and migration depends on enzyme activity or transcriptional regulation, we designed the following viruses and transfected them in MDA-MB-231 cells: vector, wild type CARM1 (CARM1 WT), EVH1 domain deletion (CARM1 ∆EVH1), and single point mutation R168A (CARM1 R168A) viruses.