We identified that PTPRM gene silencing (top 25% quartile expression vs. bottom 25%) in pancreatic cancer patients showed a significant association with poor overall survival probability (Log Rank P = < 0.05, hazard ratio [HR] = 1.82; 95% confidence interval [CI] = 0.995–4.336; P = < 0.05). This evidence concerns the gene PTPRM and familial pancreatic carcinoma.