PTPRT is a negative regulator of signal transducer and activator of transcription 3 (STAT3) and therefore promoter hypermethylation events in addition to deleterious genetic mutations may be utilized as biomarkers to inform on potential neoplasm growth in multiple tissues, responsiveness to STAT3 inhibitors [93] and predictors of standard treatments against cancer [94]. Here, STAT3 is linked to neoplasm.