The most abundant mi-RNAs within EVs generated at both small and large scales included let-7 (a, b, i)/ miR-26 (both involved in the differentiation of cells), miR-21/ miR-143 (both tumor regulators), miR-221(angiogenesis), miR-199 (tissue formation), and protein phosphatase 1 regulatory subunit 12B (PPP1R12B) (a protein phosphorylase regulator). This evidence concerns the gene PPP1R12B and neoplasm.