VEGFA and neurodegenerative disease: Case 3 of our series has shown marked bilateral reactivation of NV after initial response to VEGF followed by a prolonged inactive period of 12 months, which may be explained by a delayed response to VEGF upregulation after combined PRP and anti-VEGF intravitreal injections in this rare combination of a neurodegenerative disease with coexisting proliferative diabetic features.