AML-associated oncogenic proteins, such as MLL-AF6, MLL-AF9 and FLT3-ITD, can induce intrinsic ER stress in AML cells, resulting in higher sensitivity to the ER stress-inducing drug tunicamycin (TM) and the oxidative stress inducer arsenic trioxide (ATO) [18]. Here, KMT2A is linked to acute myeloid leukemia.