To further verify the negative correlation between CEBPA and DDIT3 gene expression, the publicly available RNA-seq data from Beat AML project and microarray data from GEO (GSE38987) (https://www.ncbi.nlm.nih.gov/gds) of AML patients were analyzed, and negative linear correlation trends were also observed in these cases (Supplementary Fig. 1A-1B). This evidence concerns the gene CEBPA and acute myeloid leukemia.