Meanwhile, KEGG pathway was enriched in neuroactive ligand receptor interaction, chemokine signaling pathway, calcium signaling pathway, hematopoietic cell lineage, primary immunodeficiency, proximal tubule bicarbonate reclamation, cytokine–cytokine receptor interaction, intestinal immune network for IgA production, glycine serine and threonine metabolism, and mismatch repair (Fig. 7B). The gene discussed is CD79A; the disease is inborn error of immunity.