Furthermore, our functional experiments showed that HBV-DNA-Pol affected the immunosuppression of T cells to some extent, and this effect was reversed after blocking with the PD-L1 antibody, which is similar to the work of Martinez et al. [34], confirming that HBV-DNA-Pol plays an immunosuppressive role in HCC by upregulating the transcription of PD-L1. The gene discussed is CD274; the disease is hepatocellular carcinoma.