Recently, patients with overlapping phenotypes of OI and EDS have been found to harbor heterozygous pathogenic variants in COL1A1 or COL1A2 [20, 21], and Morlino et al. proposed the term “COL1-related overlap disorder (C1ROD)” to consider a wide spectrum of bridging phenotypes between OI and EDS [22]. Here, COL1A1 is linked to Ehlers-Danlos syndrome.