The concentrations of both CXCL9 and CXCL10 were significantly higher in IL-10/ mice with MPE than in wild-type (WT) mice, and knockdown of the CXCL10 gene in the tumour cells led to a decrease in the recruitment of Th1 and Th17 cells into the MPE, increasing both the volume of the MPE and the mortality of the MPE-bearing mice; however, the mechanism that led to this occurrence has not yet been confirmed in human clinical studies. The gene discussed is IL10; the disease is neoplasm.