Compound probiotics (Lactobacillus rhamnosus and Lactobacillus del brueckii) prophylactically fed SLE model mice for 2 months, the levels of related autoantibodies and the frequency of Th1 and Th17 cells in the spleen were decreased; meanwhile, the serum pro-inflammatory factors IL-17 and IFN-γ levels decreased [176]. The gene discussed is IL17A; the disease is systemic lupus erythematosus.