They found that Lactobacillus can alleviate SLE-related symptoms, the possible mechanism is by inhibiting NF-κB pathway and extracellular signal-regulated kinase inflammatory pathway, thereby reducing the expression of TNF-a, IL-1β, increasing the expression of anti-inflammatory cytokines IL-10, so as to reduce inflammation. The gene discussed is IL10; the disease is systemic lupus erythematosus.