We identified 7 proteins causally associated with iridocyclitis: AIF1 (OR = 0.62; 95% CI 0.55–0.69; P = 2.92 × 10–16), VARS (OR = 0.37; 95% CI 0.26–0.51; P = 1.70 × 10–9), AGER (OR = 0.73; 95% CI 0.67–0.80; P = 2.31 × 10–11), CFB(OR = 0.81; 95% CI 0.74–0.89; P = 5.75 × 10–6), COL11A2 (OR = 1.65; 95% CI 1.44–1.90; P = 1.56 × 10–12), MICB (OR = 1.23; 95% CI 1.16–1.30; P = 1.13 × 10–12) and TAPBP(OR = 0.86; 95% CI 0.80–0.92; P = 6.34 × 10–6) (Fig. 2B,D). The gene discussed is CFB; the disease is iridocyclitis.