In analysis of subtypes of iridocyclitis, we identified 7 proteins causally associated with acute and subacute iridocyclitis, including AIF-1 (OR = 0.56; 95% CI 0.49–0.63; P = 7.86 × 10–20), VARS (OR = 0.32; 95% CI 0.22–0.45; P = 3.09 × 10–10), AGER (OR = 0.72; 95% CI 0.65–0.80; P = 1.90 × 10–10), CFB (OR = 0.78; 95% CI 0.71–0.87; P = 1.72 × 10–6), COL11A2 (OR = 1.77; 95% CI 1.52–2.06; P = 1.32 × 10–13), MICB (OR = 1.26; 95% CI 1.18–1.34; P = 3.78 × 10–13), and TAPBP (OR = 0.86; 95% CI,0.80–0.92; P = 2.45 × 10–5) (Fig. 2B, E). The gene discussed is CFB; the disease is iridocyclitis.