Though substantial observational data on the use of AT2 in real-world practice and the significance of renin and DPP3 are accumulating, the prospective interventional nature of the DARK-Sepsis trial and the inclusion of a control arm for comparison will allow us to specifically dissect whether these biomarkers serve as general prognostic markers in sepsis or if, as we hypothesize, they can be used specifically to predict response to AT2. This evidence concerns the gene REN and Sepsis.