IFNA1 and cancer: Applied to cancer, the ICR denotes activation of immune effector mechanisms in the TME such as the Th1 polarization of effector cells, production of immune-stimulatory cytokines such as interferon (IFN)-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\gamma$$\end{document}γ and interleukin (IL)-12, and the release of CXCR3- and CCR5-ligand chemokines that further attract immune cells.