TNF and congenital rubella syndrome: Furthermore, compared to activated CAR-T cells, which secrete IL-1α, IL-1Rα, IL-2, IL-2Rα, IL-6, TNF-α, MCP-1, IL-8, IL-10, and IL-15, which are highly correlated with CRS and ICANS, activated NK cells have a better safe profile, and their secretion of IFN-γ and GM-CSF relatively less likely contribute to the adverse reactions like CRS and ICANS [16–18].